multiple sclerosis

Multiple Sclerosis (MS) Drugs

Additional Reading

Multiple sclerosis, interferon beta and clinical thyroid dysfunction

"Multiple sclerosis, interferon beta and clinical thyroid dysfunction"

Kreisler A, de Seze J, Stojkovic T, Delisse B, Combelles M, Verier A, Hautecoeur P, Vermersch P; Groupe septentrional d'etude et de recherche sur la Sclerose en Plaques (G-SEP).

Department of Neurology, Lille University Hospital, France.

The objective of this study was to investigate frequency and presentation of clinical thyroid dysfunction in patients treated with interferon beta (IFN-beta).

We have collected the cases of clinical thyroid dysfunction in 700 consecutive patients receiving IFN-beta for multiple sclerosis (MS). Five patients (four women, one man) treated with IFN-beta1b developed hyperthyroidism. Three of them have secondary progressive MS, and two have relapsing-remitting MS.

It was necessary to stop IFN-beta in three cases; these patients still require carbimazole after several months. In the two other cases, hyperthyroidism disappeared spontaneously. Two patients (one man and one woman) treated with IFN-beta1a developed hypothyroidism. One of them required l-thyroxine.

Lastly, an increased thyroid volume without modification of thyroid hormones plasma levels was discovered in a patient receiving IFN-beta1a. Among patients treated with IFN-beta, clinical thyroid dysfunction is much rarer than laboratory thyroid dysfunction. However, this side-effect is sometimes severe.

Acta Neurol Scand 2003 Feb;107(2):154-7

PMID: 12580868 [PubMed link]